Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

Tung Phan; Toshiyuki Hikita; Shoko Okitsu; Yuki Akari; Satoshi Komoto; Satoshi Hayakawa; Hiroshi Ushijima

doi:10.1007/s11262-023-02018-7

Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

Tung Phan
, Toshiyuki Hikita
, Shoko Okitsu
, Yuki Akari
, Satoshi Komoto
, Satoshi Hayakawa
, Hiroshi Ushijima

医学部・ウィルス学

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.

本文言語	英語
ページ（範囲）	688-692
ページ数	5
ジャーナル	Virus Genes
巻	59
号	5
DOI	https://doi.org/10.1007/s11262-023-02018-7
出版ステータス	出版済み - 10-2023

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All Science Journal Classification (ASJC) codes

分子生物学
遺伝学
ウイルス学

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10.1007/s11262-023-02018-7

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title = "Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan",

abstract = "After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix{\textregistered} vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.",

keywords = "Evolution, G2P[4], Japan, Rotavirus, Whole genome sequencing",

author = "Tung Phan and Toshiyuki Hikita and Shoko Okitsu and Yuki Akari and Satoshi Komoto and Satoshi Hayakawa and Hiroshi Ushijima",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s11262-023-02018-7",

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T1 - Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

AU - Phan, Tung

AU - Hikita, Toshiyuki

AU - Okitsu, Shoko

AU - Akari, Yuki

AU - Komoto, Satoshi

AU - Hayakawa, Satoshi

AU - Ushijima, Hiroshi

PY - 2023/10

Y1 - 2023/10

N2 - After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.

AB - After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.

KW - Evolution

KW - G2P[4]

KW - Japan

KW - Rotavirus

KW - Whole genome sequencing

UR - https://www.scopus.com/pages/publications/85163994209

UR - https://www.scopus.com/pages/publications/85163994209#tab=citedBy

U2 - 10.1007/s11262-023-02018-7

DO - 10.1007/s11262-023-02018-7

M3 - Article

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AN - SCOPUS:85163994209

SN - 0920-8569

VL - 59

SP - 688

EP - 692

JO - Virus Genes

JF - Virus Genes

IS - 5

ER -

Whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in Japan

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UN SDG

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